PhD Scholarships Salmonella sRNA and Infection Biology
Salmonella sRNA & Infection Biology
Positions are available for two enthusiastic Ph.D. students (April 2010) with an interest in regulatory sRNA, functional genomics and Salmonella infection. The project will be led by Jay Hinton, the Stokes Professor of Microbial Pathogenesis at Trinity College Dublin, Ireland, and is funded by a Principal Investigator award to Professor Hinton from Science Foundation Ireland.
Project Outline
Since 2005, more than 80 sRNAs have been identified in Salmonella Typhimurium, by the Vogel, Altuvia and Hinton laboratories. The aim of this exciting project is to study expression of Salmonella sRNAs, and regulation of their mRNA targets, during growth of Salmonella inside mammalian cells, and other infection-related environments. The function of sRNAs will be determined in the context of the transcriptional networks of Salmonella Typhimurium. Next-generation sequencing-based RNA-Seq approaches will underpin these studies.
The Hinton lab focuses on the infection biology of Salmonella Typhimurium, using state-of-the art functional genomic technologies to study gene expression during infection, virulence gene regulation and bacterial responses to infection-relevant environmental stresses and. For more details see http://www.tcd.ie/Microbiology/research/j_hinton.php and search PubMed for “Hinton JC”.
Jay Hinton has a track record in sRNA target discovery, transcriptomic analysis of Salmonella gene expression during infection and global gene regulation. The successful candidates will join his new laboratory at Trinity College Dublin.
Salmonella is one of the most dangerous bacteria in the world. It causes 1.3 billion cases of gastroenteritis and kills 1 million people each year, worldwide. Salmonella is the second most common cause of food poisoning in Europe.
Requirements for Ph.D. scholarships: PhD scholarships applicants should have a first or upper second class honours degree (a significant component of microbiology, molecular biology or computational biology is desirable). Prior laboratory experience would be an advantage.
The PhD scholarships will be for 4 years, and the commencement date will be 1st April 2010. The Ph.D. projects will provide training in microbiology, molecular biology and genetics, functional genomics and data mining.
Post Status: Two 4-year contracts
Salary: PhD stipend: €15,263 per annum (plus 4 years academic fees for EU students)
Closing Date: 12 Noon on Friday 11th September, 2009
Further details: To learn more about the School of Genetics and Microbiology, please visit http://www.genetics-microbiology.tcd.ie/
Dublin: Dublin universities have an impressive track record in bacterial gene regulation and infection biology. Culturally, Dublin is a great city in which to live. Modern and European, traditional and Irish, it has a unique and lively atmosphere!
Interested candidates should contact Jay Hinton (jay.hinton@tcd.ie; Tel: +353 1896 1195) for an informal discussion.
Application procedure:
Candidates are invited to send PDF copies of a full CV (detailing their qualifications and experience, to include the names and contact details of 3 referees, with email addresses), together with a covering letter to:
Mr. Martin Swannell
Recruitment Executive
Staff Office
House No. 4
Trinity College
Dublin 2
Ireland
Tel: +353 1 896 8489
For applications via email: martin.swannell@tcd.ie
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